• Laura Perez-Campos Mayoral, Gabriel Mayoral Andrade, Eduardo Perez-Campos Mayoral, Teresa Hernandez Huerta, Socorro Pina Canseco, Francisco J Rodal Canales, Héctor Alejandro Cabrera-Fuentes, Margarito Martinez Cruz, Alma Dolores Pérez Santiago, Juan José Alpuche, Edgar Zenteno, Hector Martínez Ruíz, Ruth Martínez Cruz, Julia Hernandez Jeronimo, and Eduardo Perez-Campos.
• Research Centre-Faculty of Medicine, National Autonomous University of Mexico-Benito Juárez Autonomous University of Oaxaca, Oaxaca, Mexico.
• Indian J Med Res. 2020 Jan 1; 151 (1): 11-21.

AbstractObesity is a serious medical condition worldwide, which needs new approaches and recognized international consensus in treating diseases leading to morbidity. The aim of this review was to examine heterogeneous links among the various phenotypes of obesity in adults. Proteins and associated genes in each group were analysed to differentiate between biomarkers. A variety of terms for classification and characterization within this pathology are currently in use; however, there is no clear consensus in terminology. The most significant groups reviewed include metabolically healthy obese, metabolically abnormal obese, metabolically abnormal, normal weight and sarcopenic obese. These phenotypes do not define particular genotypes or epigenetic gene regulation, or proteins related to inflammation. There are many other genes linked to obesity, though the value of screening all of those for diagnosis has low predictive results, as there are no significant biomarkers. It is important to establish a consensus in the terminology used and the characteristics attributed to obesity subtypes. The identification of specific molecular biomarkers is also required for better diagnosis in subtypes of obesity.

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