Ugeskrift for laeger
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Ugeskrift for laeger · Oct 2016
Review[Reversal strategies for non-vitamin K antagonist oral anticoagulants].
Non-vitamin K oral anticoagulants (NOACs) are alternatives to vitamin K antagonists and provide consistent anticoagulation with equal or better clinical outcome and no need for routine monitoring. Bleeding is a feared complication of anticoagulants. ⋯ Andexanet alpha (expected release in 2016) and PER977 are antidotes under clinical development. This article summarizes current and potential future options to antagonize NOACs.