Ugeskrift for laeger
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Ugeskrift for laeger · Mar 2013
Review[Procedure specific pain management in relation to laparoscopic colonic surgery].
The optimal pain management in relation to laparoscopic colonic surgery remains unclarified. This article presents studies concerning the analgesic effects of paracetamol, NSAIDs, opioids, spinal and epidural blockade, transversus abdominis plane-block, infiltration and intraperitoneal local analgesics, intravenous lidocaine, gabapentinoids and corticosteroids after laparoscopic colonic resection. Moreover, side effects of the analgesics are presented and individually discussed in relation to the specific procedure. We present recommendations for pain management in relation to laparoscopic colonic resection.
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Ugeskrift for laeger · Mar 2013
Review[Genetic polymorphism affects the clinical effects of opioids after surgery].
Post-operative pain-management (PPM) should first of all be decided by the specific surgical procedure in each case, but it also seems that genetic polymorphism affects the clinical effects of the pharmacological treatment. In this article we summarize the existing evidence of the hypothesis that the A118G-variant of the µ-opioidreceptor-gene OPRM1 affects clinical response to opioids after gynaecological and abdominal surgery. If the genetic profile of each patient becomes easier accessible in the future, PPM might be planned accordingly to surgical procedure as well as to genetic profile to avoid post-operative pain and pharmacological adverse effects.