Asian Pacific journal of cancer prevention : APJCP
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Asian Pac. J. Cancer Prev. · Jan 2013
Reliability and validity of Turkish version of the caregiver quality of life index cancer scale.
Measuring effects of cancer on family caregivers is important to develop methods which can improve their quality of life (QOL) . Nevertheless, up to now, only a few tools have been developed to be used in this group. Among those, the Caregiver Quality of Life Index-Cancer Scale (CQOLC) has met minimum psychometric criteria in different populations in spite of conflicting results. The present study was conducted to evaluate reliability and validity of CQOLC among Turkish cancer family caregivers. ⋯ The Turkish CQOLC is a reliable and valid tool and it can be utilized to determine QOL of family caregivers.
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Asian Pac. J. Cancer Prev. · Jan 2013
Ischemia modified albumin levels and oxidative stress in patients with bladder cancer.
Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). ⋯ In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.
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The aim of the present study was to explore mechanisms by which let-7c suppresses NSCLC cell proliferation. ⋯ Collectively, these results demonstrate let-7c inhibits NSCLC cell proliferation and tumorigenesis by partial direct targeting of the HOXA1 pathway, which suggests that restoration of let-7c expression may thus offer a potential therapeutic intervention strategy for NSCLC.
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Asian Pac. J. Cancer Prev. · Jan 2013
Review Meta AnalysisMicroRNA-155 expression has prognostic value in patients with non-small cell lung cancer and digestive system carcinomas.
Published data have shown that microRNAs (miRNAs) could play a potential role as diagnostic and prognostic indicators in cancers. Data for the predictive value of microRNA-155 are inconclusive. The aim of the present analysis was therefore to evaluate the role of miR-155 in prognosis for patients with a variety of carcinomas. ⋯ The results indicated that the miR-155 expression level plays a prognostic role in patients with cancer, especially NSCLCs and digestive system carcinomas.