Journal of thrombosis and haemostasis : JTH
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J. Thromb. Haemost. · Apr 2012
Multicenter StudyD-dimer threshold increase with pretest probability unlikely for pulmonary embolism to decrease unnecessary computerized tomographic pulmonary angiography.
Increasing the threshold to define a positive D-dimer could reduce unnecessary computed tomographic pulmonary angiography (CTPA) for a suspected pulmonary embolism (PE) but might increase rates of a missed PE and missed pneumonia, the most common non-thromboembolic diagnosis seen on CTPA. ⋯ Doubling the threshold for a positive D-dimer with a PE unlikely pretest probability could reduce CTPA scanning with a slightly increased risk of missed isolated subsegmental PE, and no increase in rate of missed pneumonia.
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J. Thromb. Haemost. · Apr 2012
Multicenter StudyCoagulation factor activity and clinical bleeding severity in rare bleeding disorders: results from the European Network of Rare Bleeding Disorders.
The European Network of Rare Bleeding Disorders (EN-RBD) was established to bridge the gap between knowledge and practise in the care of patients with RBDs. ⋯ There is a heterogeneous association between coagulation factor activity level and clinical bleeding severity in different RBDs. A strong association is only observed in fibrinogen, FX and FXIII deficiencies.
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J. Thromb. Haemost. · Apr 2012
Comparative Study Controlled Clinical TrialReversal of the anti-platelet effects of aspirin and clopidogrel.
Guidelines recommend stopping aspirin and clopidogrel 7 to 10 days before surgery to allow time for replacement of permanently inhibited platelets by newly released uninhibited platelets. ⋯ Platelet aggregation recovers within 4 days of stopping aspirin but clopidogrel must be stopped for 10 days to achieve a normal aggregatory response.
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J. Thromb. Haemost. · Apr 2012
Comparative StudyPhenotyping vs. genotyping for prediction of clopidogrel efficacy and safety: the PEGASUS-PCI study.
Prognostic values of genotyping and phenotyping for assessment of clopidogrel responsiveness have been shown in independent studies. ⋯ Phenotyping of platelet response to clopidogrel was a better predictor of stent thrombosis than genotyping.