Pediatric blood & cancer
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Pediatric blood & cancer · Jan 2010
Multicenter StudyOcular late effects in childhood and adolescent cancer survivors: a report from the childhood cancer survivor study.
Approximately 80% of children currently survive 5 years following diagnosis of their cancer. Studies based on limited data have implicated certain cancer therapies in the development of ocular sequelae in these survivors. ⋯ Childhood cancer survivors are at risk of developing late occurring ocular complications, with exposure to glucocorticoids and cranial radiation being important determinants of increased risk. Long-term follow-up is needed to evaluate potential progression of ocular deficits and impact on quality of life.
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Pediatric blood & cancer · Jan 2010
Vaso-occlusive painful events in sickle cell disease: impact on child well-being.
This study describes how painful events affect the health-related quality of life (HRQL) of children with sickle cell disease (SCD) and determines the responsiveness of a generic HRQL measure in SCD. Our hypotheses were twofold: (1) HRQL is significantly impaired at presentation to the emergency department for a painful event and (2) PedsQL 4.0 Acute Version Generic Core Scales is responsive to change in the evolution of a painful event. ⋯ The PedsQL is responsive to change; thus a useful tool to measure the impact of interventions in future SCD clinical trials. Painful events significantly diminish all domains of HRQL and this improves 7 days post-discharge.
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Pediatric blood & cancer · Jan 2010
Costs of pediatric allogeneic hematopoietic-cell transplantation.
Allogeneic hematopoietic-cell transplantation (HCT), although curative for some high-risk diseases, is a complex and costly procedure. The costs of transplantation among children have not been described previously. ⋯ Within the first 100-days, the costs of MUD and UCB HCT are similar, while MRD HCT is less costly. These costs are primarily driven by severe post-transplant complications and graft failure.
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Pediatric blood & cancer · Jan 2010
End of life in children with cancer: experience at the pediatric oncology department of the istituto nazionale tumori in Milan.
Coping with end-stage pediatric cancer patients and the related bereavement is a challenge for all the caregivers involved. ⋯ The care of pediatric cancer patients during the end stage of their disease is the responsibility of the caregivers who have followed them up since their diagnosis. However, it would be useful to establish an exchange of information and expertise between pediatric oncologists and the other facilities involved (hospices, other hospitals) or people assisting patients at home (family, family pediatrician/general practitioner GP).