Pediatric blood & cancer
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Pediatric blood & cancer · Aug 2014
Multicenter Study Clinical TrialThe value of high-dose chemotherapy in patients with first relapsed Ewing sarcoma.
Prognosis of patients with relapsed Ewing sarcoma (ES) is poor. The 5-year overall survival (OS) is 13%. We analyzed high-dose chemotherapy (HDtx) versus conventional chemotherapy (CHtx) in patients with relapsed ES. ⋯ Additional HDtx may contribute to further reduce the risk of further events in patients who respond to conventional second-line CHtx.
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Pediatric blood & cancer · Aug 2014
Randomized Controlled Trial Comparative StudyOutpatient versus inpatient IV antibiotic management for pediatric oncology patients with low risk febrile neutropenia: a randomised trial.
Febrile neutropenia (FN) is a frequent, serious complication of intensive pediatric chemotherapy regimens. The aim of this trial was to compare quality of life (QOL) between inpatient and outpatient intravenous antibiotic management of children and adolescents with low risk febrile neutropenia (LRFN). ⋯ Outpatient cefepime management of LRFN provided significant benefit to parents and patients across several QOL domains and appeared both feasible and safe.