Pediatric blood & cancer
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Pediatric blood & cancer · Jan 2018
Mortality in children with low-grade glioma or glioneuronal tumors: A single-institution study.
While pediatric low-grade glioma/glioneuronal tumors (LGG/LGGNTs) are considered slow-growing, indolent tumors with excellent long-term prognosis, mortality due to the disease is not unknown. Few studies have addressed the cause of death in this population. ⋯ PD and PD-HGG contributed to 66% of the mortality in our patient cohort. Early psychological intervention should be included as part of the multidisciplinary management approach of children with LGG/LGGNT to reduce the risk of suicide in vulnerable subjects.
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Pediatric blood & cancer · Jan 2018
Comparative StudyAn analysis of inpatient pediatric sickle cell disease: Incidence, costs, and outcomes.
To identify characteristics of pediatric sickle cell disease (SCD) hospitalizations and to examine admission demographics and medical expenditures. ⋯ Inpatient hospitalizations for secondary manifestations of pediatric SCD were associated with significant healthcare expenditures. Patients with an increased statistical risk for death during hospitalization included Caucasians with SCD complications of ACS and VOC, and patients <1-year-old with ACS. Further research is needed to substantiate the associated clinical significance of these findings.
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Pediatric blood & cancer · Jan 2018
Case ReportsA case of neuroblastoma in DICER1 syndrome: Chance finding or noncanonical causation?
DICER1 syndrome is an inherited disorder associated with at least a dozen rare, mainly pediatric-onset tumors. Its characterization remains incomplete. ⋯ She is a carrier of a deleterious germline mutation in exon 23 of DICER1 and harbored different somatic mutations in the CN and MNG. However, no second hit was found in the NB, questioning its status as a DICER1-related tumor.