Neuroscience bulletin
-
Neuroscience bulletin · Jun 2012
Tetrahydropalmatine protects against methamphetamine-induced spatial learning and memory impairment in mice.
The purpose of this study was to investigate the effect of methamphetamine (MA) on spatial learning and memory and the role of tetrahydropalmatine (THP) in MA-induced changes in these phenomena in mice. ⋯ Repeated MA administration impairs spatial learning and memory in mice, and its co-administration with THP prevents this impairment, which is probably attributable to changed ERK1/2 expression in the PFC. This study contributes to uncovering the mechanism underlying MA abuse, and to exploring potential therapies.