Circulation. Arrhythmia and electrophysiology
-
Circ Arrhythm Electrophysiol · Apr 2010
Clinical TrialUtility of treadmill testing in identification and genotype prediction in long-QT syndrome.
The clinical diagnosis of long-QT syndrome (LQTS) remains challenging when ECG abnormalities are borderline or intermittent. Despite issues with access, cost, and heterogeneity of LQTS mutations, genetic testing remains the diagnostic gold standard for diagnosis of LQTS. We sought to develop a provocative testing strategy to unmask the LQTS phenotype and relate this to the results of genetic testing. ⋯ The presence and genotype of LQTS can be predicted by a combination of postural and exercise changes in the QT/RR relationship. beta-Blockade normalized these changes. Routine exercise testing is useful in predicting and directing genetic testing in LQTS.
-
Circ Arrhythm Electrophysiol · Apr 2010
Comparative StudyAmiodarone versus procainamide for the acute treatment of recurrent supraventricular tachycardia in pediatric patients.
Intravenous amiodarone and procainamide are both used as therapies for refractory supraventricular tachycardia (SVT). However, no studies have compared the efficacy and safety of these agents in pediatric patients. ⋯ In this cohort, procainamide achieved greater success compared with amiodarone in the management of recurrent SVT without statistically significant differences in adverse event frequency.