Bioscience trends
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Randomized Controlled Trial
Effects of premedication of midazolam or clonidine on perioperative anxiety and pain in children.
The aim of the present study was to compare clinical effects of oral midazolam and clonidine premedication in children. In a prospective randomized double blind trial, 45 children between 2-8 years old received either oral midazolam 0.5 mg/kg (group M) or clonidine at 2 microg/kg (group C 2) or 4 microg/kg (group C4). The level of sedation, quality of parental separation, mask acceptance and thermodynamics were recorded. ⋯ However, the rate of postoperative analgesia decreased significantly in group C 2 and C 4 compared to group M. The incidence of shivering was significantly increased in group M compared to group C 2 and C 4. Oral clonidine premedication can therefore provide better preoperative sedation and postoperative analgesia with few adverse effects.