Psychological medicine
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Psychological medicine · Nov 1984
Historical ArticleThe changing profile of a nineteenth-century asylum: the York Retreat.
This paper focuses on the later history of the York Retreat after the initial period for which it is best known. It discusses the marked changes which occurred in the social composition of its patients and the way in which these changes modified the asylum's management and therapy. It argues that the conventional image of the Retreat, based as it is on the institution's earliest years, needs considerable revision.
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This paper argues: (1) that analysis of the issues upon which Popper and Kuhn have been thought to differ - the possibility of conclusive falsification, the incommensurability of theories, and the existence of normal science - reveals no appreciable difference at all; (2) that the basic point of disagreement concerns the role of truth in scientific inquiry, i.e. whether or not truth should be considered the regulative ideal of science; (3) that confusion concerning these issues results from a paradigm shift in epistemology; and (4) that Popper's epistemology proves more attractive than Kuhn's for unification in psychology.
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Psychological medicine · Feb 1984
The type--token ratio in schizophrenic disorders: clinical and research value.
Prior research has indicated that the type-token ratio (TTR), a measure of repetition in language, correlates with clinical judgements of thought disorder when spoken language was examined, and differentiates statistically thought-disordered from non-thought-disordered schizophrenics and psychiatric and normal controls. We replicated this finding and examined the clinical sensitivity and specificity of the TTR measure in the diagnosis and in the assessment of thought disorder. The current clinical value of the TTR is limited, but further investigations of the nature of repetition in schizophrenic language are warranted.
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Psychological medicine · Feb 1983
A family study of HLA antigens and other genetic markers in schizophrenia.
HLA antigens and 19 other genetic marker systems were studied in 12 families containing 2 or more members diagnosed as schizophrenic. In contrast with previous reports we could exclude linkage between the disorder and HLA, and we found no evidence of linkage with Gm or Gc. ⋯ The problems of performing a linkage study in the face of diagnostic uncertainty and an unknown mode of inheritance of the main trait are discussed, and the measures taken in attempts to overcome these difficulties are described. Despite present drawbacks, genetic marker studies hold future promise as a means of detecting major gene effects in schizophrenia and other familial psychiatric disorders.