European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Nov 1978
Clinical TrialInitial clinical experience of lorcainide (Ro 13-1042), a new antiarrhythmic agent.
Lorcainide is a promising antiarrhythmic agent that belongs to the class of local anesthetics. It was tested in 7 patients with malignant ventricular arrhythmias that were resistant to other antiarrhythmic agents. ⋯ The drug was effective at rest, as assessed by 24-h dynamic electrocardiographic monitoring, and during physical exercise. Longer studies with more patients are warranted, since the drug appears to be a promising antiarrhythmic agent.