European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Aug 1999
Randomized Controlled Trial Comparative Study Clinical TrialRelative potency of controlled-release oxycodone and controlled-release morphine in a postoperative pain model.
The relative analgesic potency of single doses of oral controlled-release oxycodone and oral controlled-release morphine were compared in a randomized, double-blind trial using a postoperative pain model. ⋯ Oral controlled-release oxycodone was twice as potent as oral controlled-release morphine in this single-dose, relative potency assay. When converting patients from oral morphine to oral oxycodone, an initial oral oxycodone dose of one-half the oral morphine dose is recommended.