European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Mar 2008
Identification of severe potential drug-drug interactions using an Italian general-practitioner database.
To analyze prescriptions in a general-practitioner database over 1 year to determine the frequency, the characteristics, and the monitoring of the severe potential drug-drug interactions (DDIs). ⋯ The present study revealed that, in a group of Italian general practitioners, the risks of severe potential drug interactions are relatively low and the drugs concerned are few. Analyses of specific tests showed that physicians are generally aware of the potential risks caused by digoxin drug associations. However not all patients were closely monitored and this should be improved.