The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Apr 2009
ReviewMultiallergen immunotherapy for allergic rhinitis and asthma.
The English and non-English language literature on allergen immunotherapy was reviewed for studies simultaneously using 2 or more distinct allergen extracts in either subcutaneous or sublingual immunotherapy. Thirteen studies were identified, 11 using subcutaneous injections, 1 using sublingual administration, and 1 using both. ⋯ It is concluded that simultaneous administration of more than 1 allergen extract is clinically effective. However, more studies are needed, particularly with more than 2 allergen extracts and with sublingual administration.