Anesthesia and analgesia
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Anesthesia and analgesia · Feb 1991
Effects of sufentanil on cerebral blood flow, cerebral blood flow velocity, and metabolism in dogs.
The intracranial and systemic hemodynamic effects of sufentanil (20 micrograms/kg) were studied in 10 mongrel dogs. Baseline anesthesia was maintained with 0.7% end-tidal isoflurane and 50% nitrous oxide in oxygen. Catheters were inserted for blood pressure measurement, arterial and sagittal sinus blood sampling, radioactive microsphere injections, and intracranial pressure monitoring. ⋯ The cerebral hemodynamic changes were associated with a 35%-40% decrease in cerebral oxygen consumption. We conclude that sufentanil decreases CBF in response to decreased metabolic demand without significantly affecting intracranial pressure. Relative changes in CBF can be reproducibly monitored using TCD.
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Anesthesia and analgesia · Feb 1991
Comment Letter Case ReportsReuse of a disposable stylet with life-threatening complications.