Anesthesia and analgesia
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Anesthesia and analgesia · Nov 2011
Editorial CommentNegotiating the unanticipated costs of success.
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Anesthesia and analgesia · Nov 2011
Limb remote postconditioning alleviates cerebral reperfusion injury through reactive oxygen species-mediated inhibition of delta protein kinase C in rats.
Remote ischemic postconditioning (RPostC) is an emerging concept for cerebral infarction protection, and its potential protective mechanisms have not been well established. We attempted to investigate the implications of reactive oxygen species (ROS) and δ protein kinase C (δPKC) in neuroprotection induced by RPostC in a rat model of focal cerebral ischemia, and also to explore a possible relationship between ROS and εPKC. ⋯ These findings suggested that RPostC performed in one limb alleviated reperfusion injury after focal cerebral ischemia through ROS-mediated inhibition of endogenous δPKC activation signaling cascade in an in vivo rat model of focal cerebral ischemia.
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Anesthesia and analgesia · Nov 2011
Editorial CommentMining for mutations in malignant hyperthermia.