Anesthesia and analgesia
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Anesthesia and analgesia · Dec 2015
Observational StudyThe Effect of General Anesthesia on Aminotransferase Levels in Patients with Elevated Aminotransferase Levels: A Single-Center 5-Year Retrospective Study.
The effect of commonly used anesthetics on postoperative aminotransferase levels in patients with preoperatively elevated values is unclear. ⋯ In most cases, postoperative alanine aminotransferase levels did not worsen even in patients with preoperatively elevated levels. Sevoflurane was associated with increased odds for postoperative elevation of these levels after general surgery compared with TIVA.
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Anesthesia and analgesia · Dec 2015
Occupational Chronic Sevoflurane Exposure in the Everyday Reality of the Anesthesia Workplace.
Although sevoflurane is one of the most commonly used volatile anesthetics in clinical practice, anesthesiologists are hardly aware of their individual occupational chronic sevoflurane exposure. Therefore, we studied sevoflurane concentrations in the anesthesiologists' breathing zones, depending on the kind of induction for general anesthesia, the used airway device, and the type of airflow system in the operating room. Furthermore, sevoflurane baselines and typical peaks during general anesthesia were determined. ⋯ Anesthesiologists are chronically exposed to trace concentrations of sevoflurane during work. Inhalational inductions, LMA™, and TF air-conditioning systems in particular are associated with higher sevoflurane exposure. However, the amount of inhaled sevoflurane per day was lower than expected, perhaps because concentrations in previous measurements could be overestimated (10%-15%) because of the cross-sensitivity reaction.
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Anesthesia and analgesia · Dec 2015
Further Characterization of Hemopressin Peptide Fragments in the Opioid and Cannabinoid Systems.
Hemopressin, so-called because of its hypotensive effect, belongs to the derivatives of the hemoglobin α-chain. It was isolated from rat brain membrane homogenate by the use of catalytically inactive forms of endopeptidase 24.15 and neurolysin. Hemopressin has antihyperalgesic features that cannot be prevented by the opioid receptor antagonist, naloxone. ⋯ Here, we further confirm that hemopressins can modulate CB1 receptors and can have a slight modulatory effect on the opioid system.