The Annals of thoracic surgery
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Randomized Controlled Trial Clinical Trial
Tranexamic acid in off-pump coronary surgery: a preliminary, randomized, double-blind, placebo-controlled study.
We evaluated the hemostatic effects of tranexamic acid, a synthetic antifibrinolytic drug, in patients undergoing beating-heart coronary surgery. ⋯ In this initial series of patients undergoing off-pump coronary surgery, tranexamic acid appears to be effective in reducing postoperative bleeding and the need for allogeneic blood products.