European journal of clinical investigation
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Eur. J. Clin. Invest. · Apr 2004
Rat duodenal IRP1 activity and iron absorption in iron deficiency and after HO perfusion.
Iron regulatory protein 1 (IRP1), a post-transcriptional regulator of iron metabolism, is activated in the duodenum of iron-deficient animals, which is associated with increased iron absorption. In cell cultures IRP1 was also activated by iron-independent signals, such as H(2)O(2). Here we investigate whether luminal perfusion of rat duodenum with H(2)O(2) activates duodenal IRP1 and modulates duodenal iron absorption. ⋯ Duodenal (59)Fe uptake is not affected by the H(2)O(2)-mediated activation of IRP1.