European journal of clinical investigation
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Eur. J. Clin. Invest. · Oct 2007
Acute phase proteins do not account for unmeasured anions in critical illness.
The increasingly recognized prognostic impact of the strong ion gap in critical illness is in contrast to its largely unknown chemical nature. Experimental and clinical evidence suggest that acute phase proteins might account for elevation of the strong ion gap. The hypothesis of this investigation was that acute phase proteins account for strong ion gap in critically ill patients. ⋯ Acute phase proteins do not account for an elevated strong ion gap in critically ill patients.