European journal of clinical investigation
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Eur. J. Clin. Invest. · Mar 2024
Review Meta AnalysisThe effects of bupropion alone and combined with naltrexone on blood pressure and CRP concentration: A systematic review and meta-regression analysis of randomized controlled trials.
Considering the conflicting effects of bupropion on parameters related to cardiovascular system including blood pressure and inflammation, in this meta-analysis study, we investigated the effects of this drug alone or in combination with naltrexone on systolic (SBP) and diastolic blood pressure (DBP) and C-reactive protein (CRP). ⋯ The addition of combination therapies such as bupropion and naltrexone can significantly improve CRP levels. However, its effect on blood pressure requires proper management of this drug.
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Eur. J. Clin. Invest. · Mar 2024
ReviewSentinel lymph node biopsy for breast cancer during pregnancy: A comprehensive update.
Pregnant patients diagnosed with breast cancer (PrBC) may receive substantially different treatments compared to general population, considering that certain treatment options cannot be applied during pregnancy due to their potential harmful effects to the foetus. Regarding the use of sentinel lymph node biopsy (SLNB) in pregnant patients, potential concerns include foetal harm from radiation exposure, possible teratogenic effects of blue dyes and maternal anaphylaxis to isosulfan. ⋯ Sentinel lymph node biopsy seems to be safe and effective technique for breast cancer during pregnancy.
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Eur. J. Clin. Invest. · Mar 2024
Whole blood viscosity is associated with reduced myocardial mechano-energetic efficiency in nondiabetic individuals.
This cross-sectional study aimed to investigate the association between myocardial mechano-energetic efficiency (MEE) and whole blood viscosity (WBV) in nondiabetic adults participating in the CATAnzaro MEtabolic RIsk factors (CATAMERI) study. ⋯ WBV is associated with decreased myocardial MEE independently of other cardiovascular risk factors.
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Eur. J. Clin. Invest. · Mar 2024
Assessing the causal association between human blood metabolites and the risk of gout.
The occurrence of gout is closely related to metabolism, but there is still a lack of evidence on the causal role of metabolites in promoting or preventing gout. ⋯ This MR study combining genomics with metabolomics provides a novel insight into the causal role of blood metabolites in the risk of gout, which implies that examination of certain blood metabolites would be a feasible strategy for screening populations with a higher risk of gout.