Lancet
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Randomized Controlled Trial Comparative Study Clinical Trial
Randomised trial of epidural bupivacaine and morphine in prevention of stump and phantom pain in lower-limb amputation.
Epidural analgesia before limb amputation is commonly used to reduce postamputation pain. But there have been no controlled studies with large numbers of patients to prove such a pre-emptive effect. We investigated whether postamputation stump and phantom pain in the first year is reduced by preoperative epidural blockade with bupivacaine and morphine. ⋯ Perioperative epidural blockade started a median of 18 h (15-20.3) before the amputation and continued into the postoperative period does not prevent phantom or stump pain.
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Randomized Controlled Trial Comparative Study Clinical Trial
Randomised trial of oral morphine for painful episodes of sickle-cell disease in children.
Oral controlled-release morphine can provide effective analgesia through a non-invasive route and may facilitate outpatient management of severe episodes of sickle-cell pain. We compared the clinical efficacy and safety of oral morphine with continuous intravenous morphine in children with severe episodes of sickle-cell pain, by a double-blind, randomised, parallel-group design. ⋯ Oral, controlled-release morphine is a reliable, non-invasive alternative to continuous intravenous morphine for the management of painful episodes of sickle-cell disease in children.
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Comment Letter Historical Article
Molecular evidence for tuberculosis in an ancient Egyptian mummy.
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Randomized Controlled Trial Clinical Trial
Randomised trial of magnesium in in-hospital cardiac arrest. Duke Internal Medicine Housestaff.
The apparent benefit of magnesium in acute myocardial infarction, and the persistently poor outcome after cardiac arrest, have led to use of magnesium in cardiopulmonary resuscitation. Because few data on its use in cardiac arrest were available, we undertook a randomised placebo-controlled trial (MAGIC trial). ⋯ Empirical magnesium supplementation did not improve the rate of successful resuscitation, survival to 24 h, or survival to hospital discharge overall or in any subpopulation of patients with in-hospital cardiac arrest.