The Medical clinics of North America
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While pain can be a most useful symptom, it becomes a problem requiring attention when it causes or increases the patient's anxiety, prevents sleep, or starts the patient on a vicious cycle of increasing doses of narcotics with concomitant depression, anorexia, and lethargy. Various surgical modalities and their indications are discussed.
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Melanoma currently offers challenges to the medical profession. Opportunities for early detection, development of rational immunotherapy, and gains in curability are unparalled because of the recently defined aspects of early recognition, its cutaneous location, the long periods of superficial lateral growth, the increasing incidence, and the many fascinating immunologic aspects of melanoma.