Clinics in perinatology
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Clinics in perinatology · Sep 2012
ReviewInitial respiratory support of preterm infants: the role of CPAP, the INSURE method, and noninvasive ventilation.
This article explores the potential benefits and risks for the various approaches to the initial respiratory management of preterm infants. The authors focus on the evidence for the increasingly used strategies of initial respiratory support of preterm infants with continuous positive airway pressure (CPAP) beginning in the delivery room or very early in the hospital course and blended strategies involving the early administration of surfactant replacement followed by immediate extubation and stabilization on CPAP. Where possible, the evidence referenced in this review comes from individual randomized controlled trials or meta-analyses of those trials.
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Clinics in perinatology · Sep 2012
ReviewWhich continuous positive airway pressure system is best for the preterm infant with respiratory distress syndrome?
Various commercial and home-made continuous positive airway pressure (CPAP) systems are described in this article. CPAP may be delivered via a range of device-patient interfaces; nasal CPAP is most common, and short binasal prongs impose the least extrinsic load impedance on the infant. The source of pressure generation is categorized as either constant pressure or constant flow. The efficacy of different systems may vary according to whether lung volume recruitment, airway patency, minimization of work of breathing, or central nervous system stimulation are the primary goal of the clinical decision to use CPAP therapy.
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Clinics in perinatology · Sep 2012
ReviewControl of oxygenation during mechanical ventilation in the premature infant.
Maintenance of oxygen saturation targets is a demanding and tedious task because of the frequency with which oxygenation changes, especially in small infants receiving prolonged respiratory support. It is clear that the achievement of oxygenation targets can be improved by a higher nurse-to-patient ratio and by intense staff training. Automated control systems can also improve target maintenance, and this is achieved mainly by reducing exposure to hyperoxemia. The long-term benefits and safety of this strategy are yet to be determined in clinical trials.
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Clinics in perinatology · Sep 2012
ReviewSynchronized mechanical ventilation using electrical activity of the diaphragm in neonates.
The electrical activity of the diaphragm (Edi) is measured by a specialized nasogastric/orogastric tube positioned in the esophagus at the level of the crural diaphragm. Neurally adjusted ventilatory assist (NAVA) uses the Edi signal as a neural trigger and intrabreath controller to synchronize mechanical ventilatory breaths with the patient's respiratory drive and to proportionally support the patient's respiratory efforts on a breath-by-breath basis. NAVA improves patient-ventilator interaction and synchrony even in the presence of large air leaks, and might therefore be an optimal option for noninvasive ventilation in neonates.
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Clinics in perinatology · Sep 2012
ReviewClinical effectiveness and safety of permissive hypercapnia.
Experimental and clinical data indicate that ventilator strategies with permissive hypercapnia may reduce lung injury by a variety of mechanisms. Seven randomized controlled trials in preterm neonates suggest that permissive hypercapnia started early, before the initiation of mechanical ventilation (in conjunction with continuous positive airway pressure), followed by prolonged permissive hypercapnia if mechanical ventilation is needed is an alternative to early ventilation and surfactant. Permissive hypercapnia may improve pulmonary outcomes and survival.