Acta neurologica Belgica
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Acta neurologica Belgica · Mar 2011
The misplacement of external ventricular drain by freehand method in emergent neurosurgery.
External ventricular drain (EVD) placement is one of the most basic and common neurosurgical procedure which most was performed by young neurosurgical trainees. This study is conducted to determinate the safe and accuracy of EVD placement by freehand method. About 129 EVD placements were evaluated in this study. ⋯ The higher misplaced rate was significantly observed in patients whose head CT scans revealed the lower hydrocephalus ratio (28.85%) and the smaller ventricular size (5.6 mm). Twenty-one (16.2%) new hemorrhages associated with EVD placements were observed. Using the freehand method, EVD placement is a safe and effective procedure in management of these emergent neurosurgical diseases.
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Acta neurologica Belgica · Jun 2010
Thirty minutes of low intensity electrical stimulation promotes nerve regeneration after sciatic nerve crush injury in a rat model.
We investigated whether electrical stimulation (ES) applied directly for 30 minutes after crushing injury to the sciatic nerves of rats could improve nerve regeneration. Two groups of animals were used in this study (n = 20 each): the ES group received 30 minutes of low intensity ES (20 Hz pulse rate, 2 uA amplitude) immediately after a standard crush injury, while the control group received no stimulation after injury. Both groups were followed up for three weeks. ⋯ Additionally, axon counts, myelin thicknesses and G-ratio values were also higher in the ES group. Quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) showed an elevated expression of brain derived neurotrophic factor (BDNF) in DRG sensory neurons of the ES group five days post-injury. Here, we present the first evidence that the application of ES for 30 minutes immediately following crush injury is effective to promote nerve regeneration in a rat sciatic nerve model.
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Acta neurologica Belgica · Mar 2010
A morphological study of diffuse axonal injury in a rat model by lateral head rotation trauma.
Morphology in diffuse axonal injury (DAI) by lateral head rotation was investigated. SD rats were divided into injury (n=9) and sham (n=3) groups. A device was used to produce lateral rotational acceleration of the rats' heads. ⋯ EM provided evidence of myelin separation, peri-axonal spaces, blank areas in axoplasm, loss of microtubules, peripheral accumulation of mitochondria and clumped neurofilaments for DAI. A tendency was noted for greater labelling with NF68 as axonal damage increased. The disorderly arrangement of NFs occurred at early stage of post-traumatic axonal changes.