The Journal of the American Osteopathic Association
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J Am Osteopath Assoc · Dec 2018
Utility of 4-Factor Prothrombin Complex Concentrate in Trauma and Acute-Care Surgical Patients.
Since 2013, prothrombin complex concentrate (PCCs) have been approved in the United States for the reversal of anticoagulation induced by vitamin K antagonists. However, there has been limited investigation into their use in trauma and acute-care surgery (ACS). ⋯ Patients receiving PCC had worse outcomes than those who received FFP. Given that these differences may have resulted from baseline differences between groups, these results mandate further prospective analysis of the use of PCC in trauma and ACS patients.