Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Apr 1994
Randomized Controlled Trial Multicenter Study Clinical TrialEndometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14.
Tamoxifen is advantageous in treating all stages of breast cancer. However, studies have suggested that incidence and severity of endometrial cancer increase in women treated with tamoxifen. ⋯ Tamoxifen treatment for breast cancer should continue. In addition, the relative risk of endometrial cancer observed in B-14 tamoxifen-treated patients is consistent with the twofold relative risk used in the initial risk-benefit computation for the NSABP breast cancer prevention trial.
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J. Natl. Cancer Inst. · Apr 1994
Breast cancer among young U.S. women in relation to oral contraceptive use.
While most studies have found no association between oral contraceptive use and breast cancer, several studies of younger women have reported an association with long-term oral contraceptive use. PURPOSE. We studied the relationship of patterns of oral contraceptive use to breast cancer risk among younger women. These women have had oral contraceptives available their entire reproductive lives and are now entering the breast cancer-prone years. ⋯ Future studies should investigate whether the patterns of risk we reported are present as this cohort ages.