British journal of clinical pharmacology
-
Br J Clin Pharmacol · Feb 2011
Overdose pattern and outcome in paracetamol-induced acute severe hepatotoxicity.
Paracetamol (acetaminophen) hepatotoxicity is the commonest cause of acute liver failure (ALF) in the UK. Conflicting data regarding the outcomes of paracetamol-induced ALF resulting from different overdose patterns are reported. ⋯ Unintentional paracetamol overdose is associated with increased mortality compared with intentional paracetamol overdose, despite lower admission paracetamol concentrations. Alternative prognostic criteria may be required for unintentional paracetamol overdoses.