Journal of neurosurgery
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Journal of neurosurgery · Feb 2003
Randomized Controlled Trial Multicenter Study Clinical TrialLack of benefit of endoscopic ventriculoperitoneal shunt insertion: a multicenter randomized trial.
Endoscopically assisted ventricular catheter placement has been reported to reduce shunt failure in uncontrolled series. The authors investigated the efficacy of this procedure in a prospective multicenter randomized trial. ⋯ Endoscopic insertion of the initial VP shunt in children suffering from hydrocephalus did not reduce the incidence of shunt failure.
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Journal of neurosurgery · Feb 2003
Nerve transfers to the biceps and brachialis branches to improve elbow flexion strength after brachial plexus injuries.
In this study the authors evaluated the outcome in patients with brachial plexus injuries who underwent nerve transfers to the biceps and the brachialis branches of the musculocutaneous nerve. ⋯ The use of nerve transfers to reinnervate the biceps and brachialis muscle provides excellent elbow flexion strength in patients with brachial plexus nerve injuries.
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Journal of neurosurgery · Feb 2003
Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy.
Ionizing radiation is the gold-standard adjuvant treatment for glioblastoma multiforme (GBM), the most aggressive primary brain tumor. The mechanisms underlying neoplastic glial cell growth inhibition after administration of ionizing radiation, however, remain largely unknown. In this report, the authors characterize the response of GBM cells to ionizing radiation and elucidate factors that correlate with the radiosensitivity of these tumors. ⋯ These findings elucidate some of the molecular responses of GBMs to irradiation and suggest novel targets for future therapy.
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Journal of neurosurgery · Feb 2003
Effects of human amniotic fluid on peripheral nerve scarring and regeneration in rats.
Peripheral nerve repair surgery is still replete with challenges. Despite technical improvements in microsurgery, classic methods of nerve repair have failed to provide satisfactory results. The purpose of this study was to investigate the effects of amniotic fluid from humans on peripheral nerve scarring and regeneration in rats. ⋯ Preliminary data show that HAF enhances peripheral nerve regeneration. The preventive effect of HAF on epineural scarring and the rich content of neurotrophic and neurite-promoting factors possibly contribute to this result.
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Journal of neurosurgery · Feb 2003
Multicenter Study Clinical TrialLong-term intrathecal baclofen therapy for severe spasticity of cerebral origin.
The goal of this study was to ascertain the long-term effectiveness and safety of intrathecal baclofen (ITB) in the treatment of spasticity of cerebral origin in children and young adults. ⋯ Intrathecal baclofen provides effective long-term treatment of spasticity of cerebral origin and its effects do not appear to diminish with time. This therapy is frequently associated with adverse side effects that usually can be alleviated by adjustments in dosage.