The New England journal of medicine
-
Randomized Controlled Trial Multicenter Study Comparative Study
Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis.
Early clinical studies suggested that the anti-interleukin-17 receptor A monoclonal antibody brodalumab has efficacy in the treatment of psoriasis. ⋯ Brodalumab treatment resulted in significant clinical improvements in patients with moderate-to-severe psoriasis. (Funded by Amgen; AMAGINE-2 and AMAGINE-3 ClinicalTrials.gov numbers, NCT01708603 and NCT01708629.).
-
Randomized Controlled Trial Multicenter Study
Randomized Trial of Reduced-Nicotine Standards for Cigarettes.
The Food and Drug Administration can set standards that reduce the nicotine content of cigarettes. ⋯ In this 6-week study, reduced-nicotine cigarettes versus standard-nicotine cigarettes reduced nicotine exposure and dependence and the number of cigarettes smoked. (Funded by the National Institute on Drug Abuse and the Food and Drug Administration Center for Tobacco Products; ClinicalTrials.gov number, NCT01681875.).