The New England journal of medicine
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Randomized Controlled Trial Multicenter Study
Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke.
In acute ischemic stroke, there is uncertainty regarding the benefit and risk of administering intravenous alteplase before endovascular thrombectomy. ⋯ In Chinese patients with acute ischemic stroke from large-vessel occlusion, endovascular thrombectomy alone was noninferior with regard to functional outcome, within a 20% margin of confidence, to endovascular thrombectomy preceded by intravenous alteplase administered within 4.5 hours after symptom onset. (Funded by the Stroke Prevention Project of the National Health Commission of the People's Republic of China and the Wu Jieping Medical Foundation; DIRECT-MT ClinicalTrials.gov number, NCT03469206.).
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Letter Case Reports
Acute Cor Pulmonale in Critically Ill Patients with Covid-19.