Psychopharmacology
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Previous work has suggested that memory impairments have been associated with the recreational use of "ecstasy". This previous work, however, has not taken into consideration the additional use of cannabis amongst those examined. Cannabis use has also been associated with memory impairment. There is therefore a clear need to explore the impact of both of these illicit substances upon memory ability. ⋯ The present study provides additional evidence for longterm neuropsychological sequelae associated with the use of ecstasy, particularly with regard to delayed memory ability.
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Recent studies indicate that morphine is more potent as an antinociceptive agent in male than female rodents and monkeys. ⋯ That sex differences in the potency and effectiveness of opioids increased with decreases in the opioid's relative efficacy and with increases in the nociceptive stimulus intensity suggests that the relative efficacy of mu opioids as antinociceptive agents is greater in male than female rats.