Psychopharmacology
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Randomized Controlled Trial Clinical Trial
Characterizing the subjective, psychomotor, and physiological effects of oral oxycodone in non-drug-abusing volunteers.
The subjective, psychomotor, and physiological effects of a widely prescribed and abused prescription opioid, oxycodone, have not been studied in a population of non-drug-abusing people. ⋯ Oxycodone produced effects similar to those of other mu opioid agonists. Although oxycodone produced abuse liability-related subjective effects, it also produced unpleasant effects, a phenomenon we have observed in other opioid studies in non-drug-abusing volunteers.