Psychopharmacology
-
Randomized Controlled Trial Comparative Study Clinical Trial
Changes in food reward following smoking cessation: a pharmacogenetic investigation.
Despite the high prevalence and public health significance of weight gain following smoking cessation, little is known about the underlying bio-behavioral mechanisms or effective therapies. ⋯ These results provide new evidence that the increase in body weight that occurs following smoking cessation is related to increases in food reward, and that food reward is partly determined by genetic factors. Bupropion's efficacy in attenuating abstinence-induced weight gain may be attributable, in part, to decreasing food reward.