Neuropathology and applied neurobiology
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Neuropathol. Appl. Neurobiol. · Oct 1993
Leucotomized schizophrenics lose neurons in the mediodorsal thalamic nucleus.
It has previously been shown that chronic schizophrenic patients have a 40-50% reduction in the total number of nerve and glia cells in the mediodorsal thalamic nucleus and the nucleus accumbens compared with controls, while the total neuron and glia number is the same in the two groups in the ventral pallidum. Using new stereological cell counting methods, neuron and glia cell numbers were estimated in the mediodorsal thalamic nucleus, the ventro-medial part of nucleus accumbens and the ventral pallidum in nine brains from leucotomized schizophrenics. This number was compared with counts from control cases and chronic schizophrenics without leucotomy. ⋯ The total neuron number in ventral pallidum was normal. With frontal leucotomy it is possible to investigate the consequences of disconnection of the prefrontal cortex to central regions in the human brain. The mediodorsal nucleus of thalamus represents a major efferent projection to the prefrontal cortex.(ABSTRACT TRUNCATED AT 250 WORDS)
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Neuropathol. Appl. Neurobiol. · Jan 1982
Biography Historical ArticleEdward Weston Hurst: 1900-1980.
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Neuropathol. Appl. Neurobiol. · Nov 1979
Experimental obstructive hydrocephalus in the rat: a scanning electron microscopic study.
Hydrocephalus was induced in 12-day old rats by the cisternal infusion of a concentrated kaolin suspension. The animals were killed at day 20 and the ependymal lining of all the ventricles prepared for scanning electron microscopy. The dilation of the ventricles was moderate to gross in all cases. ⋯ Four had tears covered with small round cells, believed to be responsible for the repair of the ependyma. The third ventricle, cerebral aqueduct and fourth ventricle enlarged by incorporating folds of ependyma, present in control animals, into the ventricular walls. The circumventricular organs present in the third and fourth ventricles were not damaged by the dilation of the ventricles, even in severe hydrocephalus.