Investigative ophthalmology & visual science
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Invest. Ophthalmol. Vis. Sci. · Aug 2000
Randomized Controlled Trial Comparative Study Clinical TrialEffect of timolol, latanoprost, and dorzolamide on circadian IOP in glaucoma or ocular hypertension.
To compare the around-the-clock intraocular pressure (IOP) reduction induced by timolol 0.5%, latanoprost 0.005%, and dorzolamide in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT). ⋯ Latanoprost seemed to lead to a fairly uniform circadian reduction in IOP, whereas timolol seemed to be less effective during the nighttime hours. Dorzolamide was less effective than latanoprost but led to a significant reduction in nocturnal IOP. The reason for the difference in the pattern of the IOP curve of healthy subjects is currently unknown and deserves further investigation.
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Invest. Ophthalmol. Vis. Sci. · Aug 2000
Gene transfer of a soluble receptor of VEGF inhibits the growth of experimental eyelid malignant melanoma.
To determine the effect of adenovirus-mediated gene transfer of a soluble receptor of vascular endothelial growth factor (VEGF) on the growth of experimental eyelid malignant melanoma. ⋯ Adenovirus-mediated gene transfer of a soluble form of VEGF receptor (flt-1) gene inhibited the growth of the experimental eyelid malignant melanoma. This method may be useful as an antiangiogenic therapy for eyelid malignant melanoma.