Investigative ophthalmology & visual science
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Invest. Ophthalmol. Vis. Sci. · Dec 2013
Motion perception and driving: predicting performance through testing and shortening braking reaction times through training.
A driving simulator was used to examine the relationship between motion perception and driving performance. Although motion perception test scores have been shown to be related to driving safety, it is not clear which combination of tests are the best predictors and whether motion perception training can improve driving performance. ⋯ Tests of 3D motion perception are the best predictor of EB, while DVA velocity susceptibility is the best predictor of hazard perception. Motion perception training appears to result in faster braking responses.
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Invest. Ophthalmol. Vis. Sci. · Dec 2013
Association of TLR2 gene polymorphisms with ocular Behcet's disease in a Chinese Han population.
TLR2, TLR4, TLR8, and TLR9 have been reported to be associated with several autoimmune diseases. The current study aimed to explore whether singe nucleotide polymorphisms (SNPs) of these four genes were associated with ocular Behçet's disease (BD), Vogt-Koyanagi-Harada (VKH) syndrome, acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS), or pediatric uveitis in Han Chinese. ⋯ This study provides evidence that the TLR2 gene is involved in the susceptibility to ocular BD.
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Invest. Ophthalmol. Vis. Sci. · Nov 2013
Intravitreally transplanted dental pulp stem cells promote neuroprotection and axon regeneration of retinal ganglion cells after optic nerve injury.
To investigate the potential therapeutic benefit of intravitreally implanted dental pulp stem cells (DPSCs) on axotomized adult rat retinal ganglion cells (RGCs) using in vitro and in vivo neural injury models. ⋯ Intravitreal transplants of DPSCs promoted significant neurotrophin-mediated RGC survival and axon regeneration after optic nerve injury.
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Invest. Ophthalmol. Vis. Sci. · Nov 2013
Comparative StudyComparative study of macular ganglion cell-inner plexiform layer and peripapillary retinal nerve fiber layer measurement: structure-function analysis.
We explored and compared the relationships between the visual field (VF) sensitivities assessed by standard automated perimetry (SAP), and the ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) thicknesses as measured by Cirrus high-definition optical coherence tomography (HD-OCT) in glaucomatous eyes. ⋯ The average and sectoral GCIPL thicknesses determined by Cirrus HD-OCT were associated significantly with global and regional VF sensitivity in patients with glaucoma. The macular GCIPL thickness values may provide more valuable information than temporal pRNFL thickness values for understanding the structure-function relationships of the macular region.
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Invest. Ophthalmol. Vis. Sci. · Sep 2013
Comparative StudyGene expression profile in human trabecular meshwork from patients with primary open-angle glaucoma.
To identify the specific genes in human trabecular meshwork (TM) related to POAG. ⋯ This is the largest TM expression study of POAG cases and controls performed to date and represents the first report of TM expression in a patient having POAG with a Q368X MYOC mutation. Our data suggest the potential role of endocytic and exosome pathways in the pathogenesis of POAG.