Intensive care medicine
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Intensive care medicine · Oct 2001
Randomized Controlled Trial Comparative Study Clinical TrialSalbutamol delivery during non-invasive mechanical ventilation in patients with chronic obstructive pulmonary disease: a randomized, controlled study.
We investigated the clinical response to equivalent doses of salbutamol delivered, via metered dose inhaler (MDI) during non-invasive mechanical ventilation (NIMV-MDI), during spontaneous breathing using a spacer (MDI-Spacer), and also during intermittent positive pressure breathing (IPPB). ⋯ We show that delivery of bronchodilators via MDI with a spacer chamber during NIMV is feasible and induces a significant bronchodilator effect compared to placebo, even though it may be slightly less effective than the classical delivery system (MDI-Spacer).
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Intensive care medicine · Oct 2001
Randomized Controlled Trial Comparative Study Clinical TrialA comparison of two methods to perform a breathing trial before extubation in pediatric intensive care patients.
To compare the percentage of infants and children successfully extubated after a trial of breathing performed with either pressure support or T-piece. ⋯ In infants and children mechanically ventilated, successful extubation was achieved equally effectively after a first breathing trial performed with pressure support of 10 cmH2O or a T-piece.
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Intensive care medicine · Oct 2001
Randomized Controlled Trial Multicenter Study Clinical TrialA multi-centre, double-blind, placebo-controlled study of liposomal prostaglandin E1 (TLC C-53) in patients with acute respiratory distress syndrome.
To evaluate the safety of liposomal PGE1 (TLC C-53) in patients with acute respiratory distress syndrome (ARDS), and determine its efficacy in improving oxygenation and reducing ventilator dependency. ⋯ TLC C-53 was generally well-tolerated but failed to reduce mortality or duration of mechanical ventilation.
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Intensive care medicine · Oct 2001
ReviewSystematic review of prediction of poor outcome in anoxic-ischaemic coma with biochemical markers of brain damage.
To investigate whether accurate prognostic rules can be derived from the combined results of studies concerning prediction of poor prognosis in anoxic-ischaemic coma with biochemical markers of brain damage in cerebrospinal fluid (CSF) or serum. ⋯ Because of small numbers of patients studied and methodological limitations the combined results are not sufficiently accurate to provide a solid basis for non-treatment decisions.
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Intensive care medicine · Oct 2001
Comparative StudyAccuracy of pulse oximetry in the intensive care unit.
Pulse oximetry (SpO2) is a standard monitoring device in intensive care units (ICUs), currently used to guide therapeutic interventions. Few studies have evaluated the accuracy of SpO2 in critically ill patients. Our objective was to compare pulse oximetry with arterial oxygen saturation (SaO2) in such patients, and to examine the effect of several factors on this relationship. ⋯ Large SpO2 to SaO2 differences may occur in critically ill patients with poor reproducibility of SpO2. A SpO2 above 94% appears necessary to ensure a SaO2 of 90%.