Intensive care medicine
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Intensive care medicine · Sep 2021
Meta AnalysisPharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis.
To compare the effects of prevention interventions on delirium occurrence in critically ill adults. ⋯ Compared to placebo and benzodiazepines, we found dexmedetomidine likely reduced the occurrence of delirium in critically ill adults. Compared to benzodiazepines, sedation-minimization strategies may also reduce delirium occurrence, but the evidence is uncertain.
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Intensive care medicine · Sep 2021
Multicenter Study Observational StudyManagement of arterial partial pressure of carbon dioxide in the first week after traumatic brain injury: results from the CENTER-TBI study.
To describe the management of arterial partial pressure of carbon dioxide (PaCO2) in severe traumatic brain-injured (TBI) patients, and the optimal target of PaCO2 in patients with high intracranial pressure (ICP). ⋯ Ventilation is manipulated differently among centers and in response to intracranial dynamics. PaCO2 tends to be lower in patients with ICP monitoring, especially if ICP is increased. Being in a centre which more frequently uses profound hyperventilation does not affect patient outcomes.
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Intensive care medicine · Sep 2021
Meta AnalysisAssociation between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis.
We aimed to determine the association between sepsis and long-term cardiovascular events. ⋯ Surviving sepsis may be associated with a long-term, excess hazard of late cardiovascular events which may persist for at least 5 years following hospital discharge.