Intensive care medicine
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Intensive care medicine · Apr 2024
Multicenter Study Clinical TrialAchievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis.
Early recognition and effective treatment of sepsis improves outcomes in critically ill patients. However, antibiotic exposures are frequently suboptimal in the intensive care unit (ICU) setting. We describe the feasibility of the Bayesian dosing software Individually Designed Optimum Dosing Strategies (ID-ODS™), to reduce time to effective antibiotic exposure in children and adults with sepsis in ICU. ⋯ Dosing software may reduce the time to achieve target antibiotic exposures. It should be evaluated further in trials to establish its impact on clinical outcomes.