Intensive care medicine
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Intensive care medicine · Jun 2002
High-frequency oscillatory ventilation in experimental lung injury: effects on gas exchange.
To compare ventilation-perfusion (V(A)/Q) distributions during improvement of oxygenation caused by high-frequency oscillatory ventilation (HFOV) and pressure-controlled mechanical ventilation with high PEEP levels (CMV) in experimental acute lung injury (ALI). ⋯ In this model of acute lung injury CMV and HFOV improved gas exchange due to similar changes in V(A)/Q distribution. However, mean airway pressure had to be adjusted twofold higher during HFOV then during CMV to achieve comparable improvements in gas exchange.
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Intensive care medicine · Jun 2002
Increased endogenous carbon monoxide production in severe sepsis.
A comparison was made between the endogenous carbon monoxide (CO) production in mechanically ventilated critically ill adult patients with, and those without, severe sepsis. ⋯ Endogenous CO production was significantly higher in mechanically ventilated patients suffering from severe sepsis. Further studies are required in order to determine the mechanism(s) and the functional significance of this increase.
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Intensive care medicine · May 2002
Daily organ-system failure for diagnosis of persistent intra-abdominal sepsis after postoperative peritonitis.
To evaluate the time-course of two organ failure scores (SOFA and Goris) after surgery for postoperative peritonitis in critically ill patients according to the persistence/nonpersistence of intraabdominal sepsis (IAS). ⋯ In critically ill patients with postoperative peritonitis, the postoperative time course of the SOFA and the Goris organ failure scores was different between patients with or without intra-abdominal persistent sepsis. The lack of improvement of one of these scores on postoperative day 2 may suggest persistent intraabdominal sepsis and supports the need for a new surgical exploration.
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Intensive care medicine · May 2002
Randomized Controlled Trial Clinical TrialProne position as prevention of lung injury in comatose patients: a prospective, randomized, controlled study.
Comatose patients frequently exhibit pulmonary function worsening, especially in cases of pulmonary infection. It appears to have a deleterious effect on neurologic outcome. We therefore conducted a randomized trial to determine whether daily prone positioning would prevent lung worsening in these patients. ⋯ In a selected population of comatose ventilated patients, daily prone positioning reduced the incidence of lung worsening.