Clinical therapeutics
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Clinical therapeutics · Nov 2001
Randomized Controlled Trial Multicenter Study Clinical TrialEfficacy and tolerability of subcutaneous almotriptan for the treatment of acute migraine: a randomized, double-blind, parallel-group, dose-finding study.
The 5-hydroxytryptamine-receptor agonist almotriptan was found to be well tolerated and efficacious when administered orally in clinical trials of migraine treatment. ⋯ Almotriptan was well tolerated and significantly more effective than placebo in relieving moderate to severe migraine pain when administered as a single 6- or 10-mg subcutaneous dose.
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Clinical therapeutics · Nov 2001
Randomized Controlled Trial Comparative Study Clinical TrialComparison of cisapride and metoclopramide for facilitating gastric emptying and improving tolerance to intragastric enteral nutrition in critically III, mechanically ventilated adults.
Placebo-controlled studies have indicated that both cisapride and metoclopramide promote gastric motility in critically ill patients. ⋯ Both cisapride and metoclopramide enhanced gastric motility and improved tolerance to intragastric EN. Metoclopramide reduced gastric residual volume to a significantly greater extent than did cisapride. Only Cmax at baseline was inversely associated with residual volume.