Revista de neurologia
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Revista de neurologia · Sep 2004
[Factors affecting the arrival time of cerebrovascular disease patients at the emergency department of a Peruvian hospital].
The implementation of stroke units and of thrombolysis as treatment in cerebrovascular disease (CVD) brought about a radical change in its management, but which is influenced by the time patients take to reach the health centre following the onset of symptoms. ⋯ An important number of CVD patients (22.58%) reach the Emergency Department shortly after the onset of symptoms. Recognition of the symptoms by the person accompanying the patient and taking them to hospital by taxi are linked to early arrival, which are factors that should be taken into account when implementing an stroke unit in our area.
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Revista de neurologia · Sep 2004
Case Reports[Hereditary sensory and autonomic neuropathies. The neurophysiological and pathological aspects of two cases with congenital insensitivity to pain].
Two patients suffering from congenital insensitivity to pain were studied. They corresponded to types IV and V of the 'hereditary sensory and autonomic neuropathies' (HSAN) classification. ⋯ So far there haven't been described BR abnormalities in patients with congenital insensitivity to pain, which should be related to a trigeminal sensory impairment, which could explain the corneal ulcers that suffered these cases. BR studies should be included in the neurophysiological evaluation of the suspected small fibre neuropathies even when there are no facial symptoms shown.
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Revista de neurologia · Sep 2004
Historical Article[From empiricism to neuroscience in Alzheimer's disease].
It has been almost a hundred years since neurofibrillar degeneration in the neurones of the cerebral cortex was first described by Alois Alzheimer. This finding led to the recognition of a new disease (a presenile dementia unlike senile dementia) using the clinicopathological empirical method employed at that time. Despite Alzheimer's own opinion and the subsequent findings from many neuropathological studies, general acknowledgement of the full implications of this dichotomy has taken decades. All the cases were grouped under the eponym of Alzheimer's disease and it is now being studied with the different modern scientific methods currently available to researchers. ⋯ Alzheimer's disease has given rise to an exceptional associationist movement around the world and has become one of leading social and health problems facing the human race; its research and treatment will require the involvement of national and supranational public authorities.
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Revista de neurologia · Sep 2004
Review[Nogo-A functions during the development of the central nervous system and in the adult].
The myelin-associated inhibitors play a very important role in preventing the regeneration of the adult central nervous system. Among these inhibitors it is Nogo-A, a recently cloned protein expressed by oligodendrocytes. However, after its discovery as a myelin-associated protein, there has been described new functions for Nogo-A far from its role in the oligodendrocytes myelin. ⋯ Although Nogo-A was discovered in the context of axonal growth inhibition, in which it is indeed playing a determining role, Nogo-A has turned out to be also a neuronal protein involved in diverse processes that go from axonal fasciculation to apoptosis. As we deepened in our knowledge about the molecular mechanisms that organize the complex functioning of the CNS, it is clearer that the proteins implicated in fasciculation and axonal guidance during development also play equally important roles in mechanisms like the axonal inhibition or the regulation of the synaptic plasticity in the adult CNS.