Der Internist
-
We report a 45-year-old female patient with muscle weakness. We diagnosed renal tubular acidosis type I by laboratory findings of hypopotassemia, hypopotassuria, metabolic acidosis and basic urine. The muscle weakness improved rapidly by substitution of potassium and an alcalescent substance. Searching for associated autoimmune diseases we diagnosed primary biliary cirrhosis and initiated a therapy with ursodeoxycholic acid.
-
Pulmonary arterial hypertension is a chronic disorder of the pulmonary circulation characterized by an increased pulmonary artery pressure and an impaired cardiac function. It can present as idiopathic form or associated with several systemic diseases. Typical symptoms include progressive dyspnoea and exercise intolerance. ⋯ Treatment is based on general measures and application of pulmonary vasoactive compounds, such as prostanoids, endothelin receptor blockers and phosphodiesterase 5 inhibitors. These treatment options can be combined at progression of the disease. Lung transplantation might be an option in patients refractory to medical therapy.