Der Internist
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Review
[Less can be more-Examples on medication in older and geriatric patients from current studies].
Polypharmacy, i.e. the prescription of five or more different drugs for medicinal treatment, is a typical problem in older and geriatric patients. Polypharmacy predisposes to different negative health sequelae, such as undesired side effects, drug interactions, potentially inappropriate medication, reduced functional abilities, increased hospitalization and increased mortality. ⋯ Although concepts to reduce the number of drugs are considered necessary, in many areas there is a lack of evidence on how to limit polypharmacy in geriatric patients and to reduce and discontinue medication. This article presents examples of recent studies dealing with potentially inappropriate medication, vitamin D substitution and antipsychotic drugs, which show how to critically appraise a prescribed medication, to critically check the indications for drugs and to discontinue drug use.
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Patients with rare diseases often receive insufficient medical care. The European Reference Networks (ERNs) were initiated by the European Union to improve healthcare for patients with rare and complex diseases within Europe. ⋯ Standardization of treatment, coordination of research projects as well as training and teaching of patients, patient representatives and healthcare professionals are means to reach this goal. Virtual case discussions are offered via a web-based platform (Clinical Patient Management System), in which experts from the ERNs advise treating physicians on the diagnosis and therapy of rare diseases.
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Exceeding the need for care in general practitioner (GP) practices is a known problem that affects the work of approximately 16,000 specialists for internal medicine in the family practice context every day in Germany. In order to spare patients unnecessary treatment and measures, these must be critically questioned on a regular basis. Subclinical hypothyroidism (SH) and hyperuricemia (HU) are frequent laboratory constellations. ⋯ Furthermore, according to the studies of Li et al. and Badve et al. treatment of HU is only beneficial in the treatment of gout and nephrolithiasis and has no influence on the development of chronic kidney disease. The Canadian group of Bhatia demonstrated that the ECG for low-risk patients that is often part of health check-ups in Canada, usually results in more follow-up examinations without the groups with and without ECG differing with respect to major adverse cardiac events (MACE). Laboratory chemical analysis of N‑terminal prohormone of brain natriuretic peptide (NT-proBNP) for managing the treatment of heart failure is also not more effective than traditional treatment methods according to Felker et al., therefore, it can be discarded. "Choosing wisely", "Less is more" and the "Klug entscheiden (Smart decisions)" recommendations by the German Society for Internal Medicine are initiatives that make the process of avoiding overprovision of care accessible for all practitioners in a short and concise form.
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Cardiovascular medicine is one of the most resource-consuming parts of the healthcare system and many examples of overdiagnostic and overtreatment can be found. The present article presents just three of these, one from cardiology and two from vascular medicine. ⋯ The potential for harm caused by overdiagnostics in both cases lies not only in the unnecessary use of resources but, more importantly, in the subsequent overtreatment. The few appropriate indications are described in detail.
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High-quality medical care including the concepts of "patient-centered medicine" and "precision medicine" imply medical awareness of measures that are "too much" and thus not appropriate for certain patients in a certain context. Physicians occupy a central role as stewards of limited social resources. Numerous influencing factors can cause a cascading into medical overuse. How to identify and avoid overuse? When is "less medicine" the better medicine for an individual patient?