Annals of neurology
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Annals of neurology · Nov 2018
Randomized Controlled TrialEfficacy of Botulinum Toxin A for Treating Cramps in Diabetic Neuropathy.
Muscle cramps occur in >50% of diabetic patients and reduce the quality of life. No effective treatment is available. We evaluated the clinical effectiveness of botulinum toxin A (BTX-A) injections for treating cramps in diabetic patients with neuropathy. ⋯ Local BTX-A infiltration is an efficacious and safe procedure for obtaining a sustained amelioration of muscle cramps associated with diabetic neuropathy. Ann Neurol 2018;84:682-690.