Auris, nasus, larynx
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Auris, nasus, larynx · Jun 2013
Case ReportsDysphagia due to isoniazid therapy for tuberculosis in a patient with Lewy body dementia.
Dementia with Lewy bodies (DLB) potentially causes dysphagia; however, the features and underlying mechanism causing dysphagia have still not been clarified. We are the first to report a case of dysphagia resulting from isoniazid therapy for tuberculosis in a DLB patient. A 74-year-old woman with DLB developed dysphagia during treatment for tuberculous pleurisy. ⋯ The increased administration of levodopa successfully ameliorated dysphagia. Therefore, dysphagia was ascribed to diminished levodopa efficacy due to interaction with isoniazid. Thus, DLB patients receiving anti-tuberculous therapy should be closely examined for potential changes in swallowing and Parkinsonism.