The Journal of clinical psychiatry
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Comment Letter Comparative Study
High-risk groups for charcoal-burning suicide attempt in Hong Kong, China, 2004.
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Randomized Controlled Trial Multicenter Study
Pilot study of augmentation with aripiprazole for incomplete response in late-life depression: getting to remission.
To determine the feasibility and safety of aripiprazole augmentation for incomplete response to sequential selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) pharmacotherapy in late-life depression. ⋯ In older adults with MDD with incomplete response to SSRI and SNRI pharmacotherapy, aripiprazole was well tolerated, and symptoms of depression improved significantly during treatment with aripiprazole. A randomized, double-blind, placebo-controlled trial of adjunctive aripiprazole for incomplete response in late-life depression is warranted to further evaluate benefit and risk.
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Meta Analysis Comparative Study
The acute efficacy of aripiprazole across the symptom spectrum of schizophrenia: a pooled post hoc analysis from 5 short-term studies.
To evaluate the efficacy of aripiprazole across a range of symptoms-positive, negative, disorganized thought, depression/anxiety, and hostility-in schizophrenia and schizoaffective disorder. ⋯ In this large dataset, aripiprazole was associated with improvements in a broad range of symptom domains in the short-term treatment of schizophrenia and schizoaffective disorder.
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Severe mental illness and obesity are each serious public health problems that overlap to a clinically significant extent. Unfortunately, some of the most effective medications for severe mental illness are associated with the greatest weight gain, and the most effective strategy for severe obesity, bariatric surgery, is a treatment of last resort. ⋯ If drugs with weight-inducing effects must be used, emerging data indicate that behavioral weight management, if not already in place, should be implemented and that adjunctive pharmacotherapeutic strategies should be considered. Severe mental illness with obesity must be viewed as 2 chronic illnesses that each require long-term management.